The Week in Bio #30
Research highlights from the week
Naturally ornate RNA-only complexes revealed by cryo-EM (link). Three remarkable cryo-EM structures of RNA-only complexes. The RNA nanocages are particularly beautiful.
Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded libraries(link). Using DELs to screen for molecular glues.
Degron-modified Cas12a enhances single-cell CRISPR screening (link). Developing Perturb-seq screens using Cas12a.
Active-resent protein sensors enable continuous in vivo monitoring of inflammation (link). Very cool technology using aptamer-based molecular pendulum sensors to continuously detect protein biomarkers in vivo.
De novo design of potent CRISPR-Cas13 inhibitors (link).
Top product forecasts for 2025 (link). The metabolic space increasingly dominates the top product list.
Scalable emulation of protein equilibrium ensembles with generative deep learning (link).Development of Biomolecular emulator (BioEmu) to sample the equilibrium distributions of proteins.
Eleven clinical trials that will shape medicine in 2024 (link). Includes base editing for SCD, cannabidiol for psychosis and PRS for cancer screening.
The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution (link).