The Week in Bio #38
Research highlights from the week
All-Atom Protein Generation with Latent Diffusion (link). Preprint outlining the development of PLAID (Protein Latent Induced Diffusion) a new approach for co-generating sequence and all-atom protein structures by sampling from the latent space of ESMFold.
Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships (link). Preprint introducing CAT-ATAC, a new method for generating paired transcriptome, chromatin accessibility and perturbation identity data from single cells.
Benchmarking DNA Sequence Models for Causal Regulatory Variant Prediction in Human Genetics (link). Preprint describing TraitGym, a curated dataset of validated regulatory variants for benchmarking DNA sequence models.
Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme (link). Preprint describing the incorporation of hydrophobic non-canonical amino acids to do hydrophobic tuning.
Leveraging Large-Scale Biobanks for Therapeutic Target Discovery (link). A study doing Mendelian randomisation on over 1 million individuals across over 2,000 phenotypes.
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay (link). Paper outlining the development of a non-invasive detection system for pancreatic ductal adenocarcinoma based on serum protease activity.