SpatialAgent: An Autonomous AI Agent for Spatial Biology (link). Preprint describing the development of an autonomous AI agent for design and analysis of spatial biology experiments.
Atom level enzyme active site scaffolding using RFdiffusion2 (link). Preprint describing the use of Rosetta Fold diffusion 2 to design enzymes.
Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery (link). Preprint describing the engineering of CAR T-cells to secrete a cytokine modifier and immune checkpoint inhibitor.
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design(link). Preprint describing the development of BoltzDesign 1 to enable the design of protein binders.
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum (link). Paper describing a genome-wide association study for male and female infertility.
The response to anti-PD-1 and anti-LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming (link). Paper describing the combined use of anti-PD-1 and anti-LAG-3 therapies to overcome anti-PD1 monotherapy resistance.
No posts